Assuming Defender 200tdi and your existing transmission, this is a rough idea of what your issues will be:
1) Right side chassis bracket for motor mount needs to be fabricated such that it clears the injection pump cleanly. The 200tdi can be physically bolted up without doing this, but be prepared for it. It is not at all difficult if it needs to be done, but it does require welding.
2) Battery has to be relocated under the seat or raised.
3) Throttle linkage needs to be addressed-- probably easiest to remove the Series stuff and install a Defender pedal and cable.
4) The radiator, intercooler and pipes configuration. There are a lot of different ways of dealing with that, but the Defender components won't fit nicely without some fabrication.
5) You'll need a new exhaust system from the 200tdi downpipe all the way out the back, since you'll want a much larger diameter than you get with a 2.25 petrol.
I have a 200tdi in a 110 and I think you'll be very pleased with the performance and the economy.